Pantothen Review- Does it Cause Side Effects? UPDATED 2023

pantothen acne

Pantothenic reviews can be found on the web, but do these acne pills really work?

These pills work by reducing the natural oil in our skin called sebum with the help of ingredients including pantothenic acid. Sebum is produced naturally to keep our skin lubricated, but in some people it can be over-produced which ultimately causes side effects like oily skin and pimples.

If you are interested to see if this supplement worked for my skin, continue reading the Pantothenic acne pills review below. Read more about what you need to know about this acne treatment pill.

oily skin pills

My Pantothen Order

I was really impressed with the look of their website and that you could pay with PayPal as that is how I prefer to pay online.

Pantothen Price

I purchased one bottle of the Panothen acne pills for $39.95 and picked the cheapest shipping option of plus $6.95 which was USPS First Class with tracking confirmation. I use USPS a lot and the price of $6.95 for First Class shipping is overpriced. It should only be around $2-$3.

$39.95 is also the most expensive product that I have tried for a 30 day supply.

I did not have a Pantothen discount code when I made my purchase.

The Pantothen order tracking was e-mailed to me 5 days after placing my order and the bottle was delivered 4 days after receiving the tracking information. A Pantothen track order link was included in the e-mail as well so I would know exactly when it would be delivered.

If you are not satisfied with your Pantothen acne pills you can return the bottle within 90 days as they have a 100% money back guarantee. You will need to pay for your own shipping when sending the bottle back and e-mail them with your tracking number to ensure the process of reimbursement.

My Pantothen Tablets Review

pantothen acne pills

Pantothen Dosage

On the Pantothen label it says to take 4 tablets a day and there are 30 servings per container. One bottle of acne treatment tablets will last exactly 30 days.

I do not have a problem swallowing pills, but the Pantothen pill size is BIG. Of all of the acne pills we have reviewed these are by far the biggest ones.

The Pantothen directions say to take the pills spread out throughout the day. The company recommends taking the Pantothen tablets in the morning, afternoon, late afternoon, and evening. They may recommend taking the pills this way just to make the customer used to taking the product on a regular basis, but that is just a guess.

It may not be realistic to have people on such a strict schedule and it may not be based on any kind of science. Many people already have trouble swallowing pills and having them do it four times a day may be excessive.

I took all of the Pantothen acne pills in the morning and did not take them spaced out throughout the day. It may not be necessary to space them out if you don't want to, but an advantage of taking the pills spaced out may be that you could possibly get a more even release so that there aren’t dips in the effectiveness. I do not see much benefit in the trouble of taking it like this nor have I seen a difference in results in similar products.

My advice is to learn to get into a routine of taking them so you don't forget. Over time it will become easy to remember.

Another possible benefit of taking the Pantothen acne pills spaced out throughout the day is that taking supplements with food in your stomach helps the absorption and digestion which may prevent nausea. I took mine on an empty stomach and did not have an issue, but other people might.

How Long Does It Take to Work?

I noticed a change in my skin within one day of taking it. I noticed my skin looked more even and tight almost like I had gotten a facial. Some people may not see fast results as I did and may have to take it for months to see great results. I guess my face was more oily than normal because my face did not get dry or flaky, but a sign that showed reduced oil production was that my lips got really dry. Nothing a little chap-stick or coconut oil won't fix! 

My Pantothen review is based on one week of taking it consistently. I was also taking one tablet of Biotin (10mg) along with taking Pantothen. Bad side effects like hair loss or increased breakouts because of the imbalance of Biotin and Pantothenic acid did not occur in me personally when I took it. These symptoms are things to look out for and have been reported.

Is Pantothen Effective?

I feel the product does work as I took the product for many days in a row and did not have any breakouts. I also noticed that my complexion seemed better as my skin looked tight and not oily while taking Panothen. Work up to the dose you feel is necessary as you may not need to take four pills a day especially if you experience overly dry skin. 

You may get even better results when using a topical treatment along with Pantothen. Acne side effects like redness and inflammation can be helped with creams like benzoyl peroxide and salicylic acid. These products help to dry out your skin even more, but the more you use the more your skin may become too dry.

Can You Buy Pantothen in Stores?

Pantothen is sold in stores such as Walmart in the United States

Where Else Can You Buy Pantothen?

Pantothen is for sale on their English site and you can also buy it online on websites such as eBay. It is also available in the UK, Ireland, Canada, Australia, New Zealand, and South Africa, but not in the Philippines.

After you place an order with them your e-mail will be in their system and you may receive a Pantothen voucher code on occasion in case you want to place another order. 3 weeks after I placed my order I had received an e-mail with a Pantothen coupon for %15 off.

Does Pantothen Have a Contact Number?

You can only contact Pantothen through an email form online. They will address questions, inquiries, and feedback within 48 hours in most cases.

tablets for spots

If you want clear skin in the UK check out Blemless.

Pantothen Customer Reviews

There aren't many Pantothen pill reviews on Amazon as their listing looks fairly new.

Of the few Panothen for acne reviews, there are mostly positive ones stating that their complexion looks much better and that it has helped their hormonal breakouts. There aren't many bad or negative reviews on Pantothen.

pantothen natural acne solution reviews

One customer said that it made their skin smoother, but side effects that they mentioned were more breakouts of cystic acne, blackheads, and whiteheads which they included in their Pantothen review. Side effects like these I have found are very common among acne products as some people respond better to different ingredients than others.

pantothen review

There aren't any Pantothen before and after photos on Amazon, but you may be able to see some from Pantothen Youtube reviews. You can also find more reviews on Yahoo Answers and YouTube.

There aren't many Pantothen UK reviews because the listing is new, but it does have a positive star rating. Unlike the Pantothen US customers, the UK customers did not go into specific detail about how the product has helped their skin.

Surprisingly there aren't any Pantothen acne treatment reviews on either.

What are the Pantothen Benefits and Side Effects?



Reduces oily skin.

May experience more pimples.

Stops new breakouts from occurring.

May experience dry lips and skin.

Improves overall complexion.

May cause hair loss.

Because there is an imbalance of Biotin and Panothenic acid in Pantothen, hair loss may be experienced. For this reason you may want to take a Biotin supplement as well.


Always read labels, warnings, and directions before consuming this product. If you experience any severe side effects or problems seek medical attention immediately.

oily skin pills

What Are the Ingredients of the Pantothen Tablets?

Pantothen ingredients list with mg:




1.5 mg


1.7 mg


20 mg

Vitamin B6

2 mg


400 mcg

Vitamin B12

6 mcg


300 mcg

Pantothenic Acid

2200 mg


733.3 mg


Thiamin (also spelled 'Thiamine') is a water soluble B-vitamin. B-vitamins help metabolize proteins, carbs, and fats in the body for energy. It works synergistically with other B-vitamins to produce a more powerful effect. Vitamin B deficiency can make our skin become dry and itchy. 

This vitamin has been shown to have antioxidant properties (1) which help with the slowing of the aging process which includes wrinkles and age spots.

Along with skin benefits, Thiamin may also help the heart, prevent cataracts, aid in digestion, improve memory and improve appetite. (2)

The RDA (recommended daily allowance) for adults 18 years and over is 1.2 mg. For other issues including Alzheimer's, menstrual cramps, epilepsy, and alcohol withdrawal, an amount of up to 100 mg can be taken. (3)


Riboflavin (vitamin B2) is another B-vitamin which also has antioxidant effects in the body that help protect against free radicals which is anything foreign that may damage cells growth.

It is a water soluble vitamin which means that it is necessary that we receive enough of it in order to prevent deficiency. You can detect deficiency if you notice skin inflammation like acne or other skin disorders especially on the face. (4)

If you are taking oral or topical prescription Tetracycline antibiotics for acne, Riboflavin may decrease the amount of absorption of the drugs and therefore may make the medication less effective. (5)

For adults 18 years or older the RDA is 1-1.3 mg, but more can be taken for specific issues and since it is water soluble you are at less of a risk of toxicity as whatever excess your body does not use gets excreted out in the urine.


Niacin is another part of the B-vitamins (b3) and is water soluble as well. It can help increase circulation throughout the entire body which is important for our skin because poor circulation can lead to blotchy and uneven skin tone.

Increased circulation will decrease the amount of inflammation in the body which may help with increased breakouts and other skin disorders like rosacea.

It has also been shown to help aging skin by smoothening out wrinkles as it prevents photocarcinogenesis which is the creation of cancer cells after exposure to light.

The RDA for Niacin is 14-16 mg.


This is another water soluble B-vitamin which works synergistically with the other B-vitamins in this stack to help clear skin.

Although this vitamin B6 is needed for healthy skin, too much of it can actually have the opposite effect that we want for our skin which is increased breakouts as shown in this scientific study.

Females may be more affected by pimples than males when taking high doses of vitamin B6.

The RDA for vitamin B6 is 1.3-1.7 mg. I believe this ingredient is added in at the right dose for effectively helping clear skin without increasing breakouts.


Folate is also known as vitamin B9 and is water soluble. It is extremely beneficial for our overall health as it helps the cells in the body function properly, helps prevent against heart disease, protects against birth defects, and may also help with mood and depression. (7)

People wonder if there is a difference between folate and folic acid. Folic acid is the synthetic form of folate and is usually found in supplements, however the term "folate" often describes both natural and synthetic versions so we can not be sure which form of folate is in this product. (8)

The RDA of folate is 400-600 mcg.


Vitamin B12 when taken in high doses along with vitamin B6 may increase acne.

People with clear skin as well as acne sufferers have Propionibacterium acnes on the skin which is the bacteria that contributes to breakouts, but the bacteria on the skin of acne sufferers are more active than on people with clear skin according to a report in Science Translational Medicine. It was found that over consumption of vitamin B12 caused breakouts in people with more of these bacteria on the skin.

The RDA of vitamin B12 is 2.6-2.8 mcg. It is not known for sure how high of a dose of vitamin B12 causes breakouts, so it is best to monitor how much you take if you see an increase in pimples.


Biotin plays a role in the development and maintenance of healthy skin, hair, and nails. If you have a Biotin deficiency you may notice brittle nails, skin problems, and hair loss.

The RDA of Biotin is 300 mcg.


Pantothenic acid or vitamin B5 (also known as Pantothenate) has many health benefits for our skin and overall health. The purposes of this vitamin include reducing stress by lowering cortisol levels, lowering the risk of heart disease, and helping to support our immune system.

Studies have shown that it has a specific effect on the skin as mega-dosing Pantothenic Acid can help reduce inflammatory blemishes such as acne (9).

Vitamin B5 may also help reduce oily skin because it is converted into Coenzyme-A in the body. Coenzyme-A helps to break down the fatty acids that are contributed the production of sebum which is the oil that is secreted from our skin. A study conducted by Dr. Leung showed that breakouts occurred when the body lacked an efficient amount of Pantothenic Acid.

RDA of Pantothenic Acid is 5 mg. There are no real main side effects of taking large doses of B5 except diarrhea, but you would have to take even more than the amount that is in Pantothen. Weight loss may occur if you take large doses of B5 as it helps the breakdown of fats, carbohydrates, and proteins and increases our metabolism.


L-Carnitine is an amino acid which transports fatty acids from all major organs to the mitochondria or "powerhouse of the cell" to be burned for energy. If L-Carnitine decreases in our body it is almost undeniable that we will see faster aging, increased fatigue, and increased body fat as our body can not make the energy necessary to support these important functions from the major organs in our body.

Some benefits of L-Carnitine include weight loss as it helps reduce fatigue and appetite, as well as boosting the immune system and protecting against heart disease. (10)

Because it is has antioxidant effects, it may help skin issues caused by inflammation like acne and rosacea. Studies have showed that applying it topically has a higher bioavailability which will more effectively reduce sebum. (11)

There are four types of carnitine; L-Carnitine, Acetyl-L-carnitine (ALCAR), L-Carnitine L-Tartrate (LCLT) and Propionyl-L-Carnitine. They play different roles in the body depending on their chemical composition.

For example, ALCAR crosses the blood-brain barrier and has a slight stimulant effect which is why it is added into nootropic supplements like Addrena for enhanced cognition while L-Carnitine helps overall body function.

The type that is added into this supplement is L-Carnitine Tartrate which reduces oily skin and prevents formation of pimples.

The required amount of L-Carnitine according to the RDA is between 500-2,000 mg.

Some of the ingredients in Pantothen are in 'mg' while others are in 'mcg' as they represent different systems of measurement.

A microgram (mcg) is equivalent to a thousandth of a milligram and is the smallest unit.

A milligram (mg) represents a thousandth of a gram and because it is larger, it is more commonly used than mcg.

The reason why some ingredients are in mg and some are in mcg is because the lower amounts of ingredients that are in mcg would have to be written with a decimal point if they were mg.

Can You Take Pantothen During Pregnancy?

We do not recommend any woman who is pregnant to take supplements without their professional doctor's permission. There is a lack of clear evidence about the interactions that supplements may have on the fetus as each woman is individually different.




Vit B6


Vit B12


Vit B5


Likely Safe

RDA (pregnancy)

1.4 mg

1.4 mg

18 mg

1.9 mg

400 mcg

2.6 mcg

30 mcg

  6 mg

        2 g


Thiamin is important during pregnancy because it helps convert food into energy and keeps the muscles, heart, and nervous system functioning properly.


Riboflavin deficiency is rare, but pregnant women who consume a vegetarian-like diet by not eating meats or dairy products may increase the risk of preeclampsia which is high blood pressure caused by pregnancy.


According to the FDA, Niacin is under the Pregnancy Category C because there is a lack of evidence showing the effects that it could have on the fetus especially in large doses over the recommended daily allowance.

Vitamin B6

Vitamin B6 has been used for morning sickness and is included in many pre-natal vitamins.


Folate is also included in many pre-natal vitamins and may help prevent birth defects.

Vitamin B12

Vitamin B12 is important during pregnancy in the correct dose. Low levels during pregnancy may be linked to birth defects such as Neural Tube Defect (NTD) while high doses during pregnancy may be linked to autism as found by researchers at Johns Hopkins University, Baltimore. (12)


Pre-natal vitamins already contain Biotin, but 30%-50% of pregnant women have low levels of Biotin because it becomes depleted when the fetus grows (13). Even though Biotin decreases during pregnancy, there is a lack of clinical evidence on humans showing that increasing the amount of this vitamin will produce a healthier pregnancy so it is still recommended to stay within the daily dosage.


Carnitine is likely safe when taken in the form of L-Carnitine or L-Carnitine Tartrate and has been shown to increase low plasma levels which become depleted during pregnancy (14). By the 12th week of pregnancy, this amino acid is already significantly reduced and lessens even more before birth.

It was also shown in a study published in Chemical Monthly that lower levels of L-Carnitine in pregnant women lead to the decrease of certain enzymes which are involved in the metabolism of fatty acids. The researched found that taking 2g of an L-Carnitine supplement helped increase these certain enzymes.

oily skin pills

Pantothen vs Clearzine

I have taken both products and I had more success with Panothen than Clearzine. In my Clearzine review I documented that although it helped some pimples clear up, existing ones were still there and did not go away. I also needed to take a topical spot treatment along with the supplement to increase the effects of eliminating acne.

If you are wondering if Pantothen or Clearzine is more effective, I would say try Pantothen. Every one reacts to supplements differently and people may experience more results from these acne pills than the other. ClearZine on one hand has the smallest pills while Pantothen has the largest and although ClearZine was not as effective, it is much cheaper.

Pantothen vs Acnepril

Many people wonder which is better, Pantothen or Acnepril? From my personal experience I think that Pantothen is better as although it contains less overall ingredients, they are more effective for helping skin issues.

In my Acnepril review I documented that I actually experienced new breakouts when taking the supplement whereas with Pantothen I didn't experience any breakouts at all.

Pantothen vs Pantothenic Acid

Pantothen contains a large amount of pantothenic acid among other secondary ingredients which are added in at a very low dose. Most of the results from Pantothen are likely from the vitamin B5 as the other ingredients don't seem as effective.

Is Pantothen Safe?

Pantothen is likely safe for people to take, but if you are on any medication, suffering from an illness, pregnant, or have some other kind of disorder you must discuss your use of the product with your doctor to ensure there are no negative interactions.

Does Pantothen Work and Do These Acne Pills Produce Results?

It may not work for some people because many people won't want to take 4 large pills in a day for an extended period of time. It seems like work to keep track of when you have taken each pill of Pantothen. How to take it is up to the individual as I suppose you could take them all at once, but the company recommends to take them spaced out throughout the day.

So is Pantothen the natural acne solution that will clear your acne completely? It is not a complete skin care stack and because of the imbalance of Biotin it could cause hair loss, but a lot of people may get results from this stack too.

CONCLUSION: Is Pantothen Good or Bad?

It really depends on how oily your skin is and the types of breakouts you have. Overall this product may help your skin as it is not a scam, it is just a little overpriced and oversized and will not cure acne permanently. People also wonder "is Pantothen fake?". I do not believe they are the best acne pills, but they are not fake because they helped keep my skin clear and breakout free and I would continue to use them in my beauty regimen.

Of course we need to keep in mind our nutrition and the dietary foods we eat as the Standard American Diet is full of highly processed and high-glycemic foods that contain chemicals which cause side effects such as breakouts and other negative health effects. Adding supplements and reducing intake of harmful foods along with a healthy lifestyle will increase your chances of reducing pores and pimples.

What has worked best to help rid your acne? Please leave a comment below and let us know.

Read all possible reactions associated with this product and consult a doctor before the start of use. The advice in this article is not meant to replace any treatments or therapy for an skin condition. Do not use this information as an alternative to current medications you are taking to control medical conditions.